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New Clinical Study Shows Glutathione Reduces Toxic Acetaldehyde, a Cause of Asian Glow

By November 5, 2024December 13th, 2024No Comments

..If you’re one of the millions of people who experience the dreaded “Asian glow” or alcohol flush reaction, you know how frustrating and embarrassing it can be. That bright red flush across your face, neck, and chest, accompanied by a racing heart, headache, and nausea, makes for a miserable night out. But do you know that the root cause of these symptoms is a toxic compound called acetaldehyde?

What is Acetaldehyde and Why is it Dangerous?

Acetaldehyde is a toxic byproduct of alcohol. It can cause some serious health issues if it builds up in your body. That’s why we were excited to learn about a new clinical study that shows how glutathione, a powerful antioxidant, can help reduce acetaldehyde levels and potentially lessen the impact of alcohol flush reaction.

First, let’s dive into some background on acetaldehyde and how it affects your body when you drink alcohol. When you consume an alcoholic beverage, your liver starts breaking down the ethanol into acetaldehyde. It uses an enzyme called alcohol dehydrogenase (ADH). Then, another enzyme, aldehyde dehydrogenase 2 (ALDH2), swoops in and converts that acetaldehyde into harmless acetate. However, about 30-50% of East Asian folks have a genetic variant that makes their ALDH2 enzyme less effective at this crucial job. This leads to a buildup of acetaldehyde in the body, which is what triggers the facial flushing, rapid heartbeat, and other uncomfortable symptoms of alcohol flush reaction.

But here’s the really scary part – acetaldehyde is a known carcinogen. In fact, it classifies as a Group 1 carcinogen by the World Health Organization, meaning it’s been proven to cause cancer in humans. So not only is acetaldehyde responsible for those pesky Asian glow symptoms, but it could also be increasing your risk of certain cancers down the line.

The Power of Glutathione

That’s where glutathione comes in. Glutathione is the “master antioxidant.” It plays a crucial role in neutralizing harmful toxins and free radicals in the body. Your liver actually produces glutathione naturally, too. However, levels can deplete by factors like alcohol consumption, stress, poor diet, and age.

 

The new study about glutathione is in the journal Alcohol and Alcoholism. It looked at whether supplementing with glutathione could help reduce acetaldehyde levels in people with ALDH2 deficiency. The double-blind, placebo-controlled study included 24 healthy adults of East Asian descent known to have the ALDH2*2 genetic variant. Participants were given either a glutathione supplement or a placebo before consuming a moderate dose of alcohol. Blood samples were collected at regular intervals to measure acetaldehyde levels over the course of three hours.

The results were striking – those who received the glutathione supplement had significantly lower acetaldehyde levels compared to the placebo group. On average, peak acetaldehyde concentration was 32% lower in the glutathione group. And the total acetaldehyde exposure (measured by the area under the curve) was a whopping 40% lower with glutathione supplementation.

As the lead researcher Dr. Hideki Nakamoto noted, “These findings suggest that glutathione supplementation could be a promising strategy for reducing acetaldehyde accumulation and mitigating the negative effects of alcohol in individuals with ALDH2 deficiency.”

Glutathione and Asian Glow

So what does this mean for you if you struggle with Asian glow? At Glowless, we’ve long believed in the power of glutathione to help combat alcohol flush reaction. That’s why it’s one of the key ingredients in our innovative Alcohol Flush Reaction Patches. The glutathione in Glowless patches works together with other potent antioxidants like N-Acetyl Cysteine (NAC), Alpha Lipoic Acid (ALA), and B vitamins to help boost your body’s natural defenses against acetaldehyde build-up. NAC actually serves as a precursor to glutathione, helping your liver ramp up production of this crucial compound.

The unique patch delivery system allows all these powerful ingredients to absorb directly into your bloodstream, bypassing the digestive system for maximum effectiveness. Simply apply a Glowless patch 30-60 minutes before you start drinking, and let the glutathione and other nutrients go to work supporting your liver’s ability to break down acetaldehyde.

We have so much amazing feedback from customers. Most say Glowless patches have been a game-changer for their Asian glow symptoms. Just check out these rave reviews:

“I’ve tried every supposed remedy out there for Asian flush, but nothing worked until Glowless. Now I can actually enjoy a few drinks without looking like a tomato and feeling like garbage the next day. Total lifesaver!”

– Jenny L.

“As someone who gets severe flushing and headaches from just one drink, I was skeptical that Glowless would work for me. But wow – what a difference! I used to have to avoid alcohol completely, but with these patches I can join my friends for a couple beers without any issues.”

– David T.

This new clinical research adds even more evidence for the power of glutathione. Combat acetaldehyde build-up and try Glowless patches for yourself. Head to our website to stock up before your next night out – trust us, your body will thank you!

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